Meeting Banner
Abstract #0253

Ex vivo gray matter is complex: exchange & disorder exponents

Ileana O Jelescu1,2 and Quentin Uhl1
1Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, 2CIBM Center for Biomedical Imaging, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland


Fixation alters tissue properties significantly and in vivo vs ex vivo models should be adapted accordingly. Unlike in vivo studies of rodent gray matter (GM) where diffusion time-dependence D(t) was absent for t > 10 ms, allowing an interpretation of time-dependent kurtosis K(t) as resulting from inter-compartment exchange, here we show that ex vivo rodent GM displays marked D(t), with non-Gaussianity arising most probably from extracellular water. K(t) could thus result from combined effect of disorder and exchange. High-b data where extracellular water is preferentially suppressed may still enable the unconfounded estimation of exchange.

This abstract and the presentation materials are available to members only; a login is required.

Join Here