Synthetic Multi-Contrast Late Gadolinium Enhancement Using Post-Contrast Cardiac MR Fingerprinting
Imran Rashid1,2, Varun Rajagopalan1,2, Sadeer Al-Kindi1,2, Sanjay Rajagopalan1,2, Nicole Seiberlich3,4, and Jesse Ian Hamilton3,4
1Cardiology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, 2Medicine, Case Western Reserve University, Cleveland, OH, United States, 3Radiology, University of Michigan, Ann Arbor, MI, United States, 4Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States
A technique is introduced using post-contrast cardiac Magnetic Resonance Fingerprinting (MRF) T1 and T2 maps to calculate synthetic late gadolinium enhancement (LGE) images with multiple contrast weightings, including bright-blood magnitude inversion recovery images, dark-blood T2-prepared inversion recovery images, and a novel contrast weighting (optimized for each patient) designed to improve differentiation among viable myocardium, blood, and scar based on measured T1 and T2 values. Initial results are presented in fifteen patients with ischemic cardiomyopathy scanned at 1.5T using conventional LGE and MRF-derived multi-contrast LGE images.
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