Meeting Banner
Abstract #0337

Deoxyhemoglobin versus Gadolinium as Contrast in Dynamic Susceptibility Perfusion Imaging: Simulations and Scan Validations

Jacob Benjamin Schulman1, Ece Su Sayin2, Julien Poublanc3, Angelica Manalac1, Joseph A Fisher4, Olivia Sobczyk4, James Duffin4, Harrison Levine2, David J Mikulis3, and Kamil Uludag5
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physiology, University of Toronto, Toronto, ON, Canada, 3Joint Department of Medical Imaging and the Functional Neuroimaging Lab, University Health Network, Toronto, ON, Canada, 4Department of Anaesthesia and Pain Management, University Health Network, Toronto, ON, Canada, 5Techna Institute & Koerner Scientist in MR Imaging, University Health Network, Toronto, ON, Canada


DSC-MRI requires bolus administration of gadolinium, an exogenous contrast agent with notable limitations. We used simulations to compare gadolinium with a deoxyhemoglobin bolus generated in the lungs as perfusion contrast and verified the findings in healthy human subjects. We found that the calculated cerebral blood volume is dependent on the contrast agent, the magnitude of deoxyhemoglobin concentration increase (dosage), and the baseline oxygen saturation. We also found a reduction of macrovascular contamination with deoxyhemoglobin contrast. This work reveals novel insights for the use of deoxyhemoglobin, an endogenous and safe contrast agent for determining perfusion in the human brain.

This abstract and the presentation materials are available to members only; a login is required.

Join Here