Abstract #0337

Deoxyhemoglobin versus Gadolinium as Contrast in Dynamic Susceptibility Perfusion Imaging: Simulations and Scan Validations

Jacob Benjamin Schulman¹, Ece Su Sayin², Julien Poublanc³, Angelica Manalac¹, Joseph A Fisher⁴, Olivia Sobczyk⁴, James Duffin⁴, Harrison Levine², David J Mikulis³, and Kamil Uludag⁵

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physiology, University of Toronto, Toronto, ON, Canada, ³Joint Department of Medical Imaging and the Functional Neuroimaging Lab, University Health Network, Toronto, ON, Canada, ⁴Department of Anaesthesia and Pain Management, University Health Network, Toronto, ON, Canada, ⁵Techna Institute & Koerner Scientist in MR Imaging, University Health Network, Toronto, ON, Canada

Synopsis

DSC-MRI requires bolus administration of gadolinium, an exogenous contrast agent with notable limitations. We used simulations to compare gadolinium with a deoxyhemoglobin bolus generated in the lungs as perfusion contrast and verified the findings in healthy human subjects. We found that the calculated cerebral blood volume is dependent on the contrast agent, the magnitude of deoxyhemoglobin concentration increase (dosage), and the baseline oxygen saturation. We also found a reduction of macrovascular contamination with deoxyhemoglobin contrast. This work reveals novel insights for the use of deoxyhemoglobin, an endogenous and safe contrast agent for determining perfusion in the human brain.

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