Development of perfusion technique with dynamic BOLD MRI and transient hypoxia in mouse
THI THUY LE1, DONG KYU LEE2, GEUN HO IM2, and SEONG GI KIM1
1Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea, Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Republic of Korea, Suwon, Korea, Republic of, 2Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Republic of Korea, Suwon, Korea, Republic of
Tissue perfusion can be measured by arterial spin labeling and dynamic susceptibility contrast (DSC) method. However, these methods cannot be easily applied to mouse. Alternatively, a bolus of paramagnetic deoxyhemoglobin induced by transient hypoxia may be used as an endogenous blood pool contrast agent. Dynamic BOLD MRI with hypoxic challenge was adopted in mice. A stimulus duration was determined, and its impact to animal physiology was investigated. With corrected arterial input function, quantitative CBF and CBV were determined. Overall, we successfully developed a technique with BOLD MRI and transient hypoxia.
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