Tissue perfusion can be measured by arterial spin labeling and dynamic susceptibility contrast (DSC) method. However, these methods cannot be easily applied to mouse. Alternatively, a bolus of paramagnetic deoxyhemoglobin induced by transient hypoxia may be used as an endogenous blood pool contrast agent. Dynamic BOLD MRI with hypoxic challenge was adopted in mice. A stimulus duration was determined, and its impact to animal physiology was investigated. With corrected arterial input function, quantitative CBF and CBV were determined. Overall, we successfully developed a technique with BOLD MRI and transient hypoxia.
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