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Abstract #0359

Multi-shot DW-EPI using a modified interleaving scheme and second-order motion-compensated diffusion sensitization

Eric Seth Michael1, Franciszek Hennel1, and Klaas Paul Pruessmann1
1Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland


Multi-shot techniques for diffusion MRI are desirable because of the associated improvement potential in image resolution but are inhibited by phase variability across interleaves, which results from subject motion and causes ghosting. Here, an EPI-based acquisition strategy is devised which diminishes the ghosting pattern by employing a modified interleaving scheme and mitigates motion sensitivity by nulling the first- and second-order moments of the diffusion-sensitizing gradient waveforms. This solution yielded unperturbed, high-resolution images in in vivo human brain scans and clear improvements in image quality compared to acquisitions incorporating standard interleaving and uncompensated diffusion sensitization.

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