High-resolution diffusion-weighted MRI is susceptible to head movement artifacts and background phase variations. We investigate a crucial combination of prospective motion correction and Spatial-angular local low rank (SPA-LLR) constrained reconstruction to obtain robust multi-shot high-resolution diffusion-weighted MRI under substantial motion. Prospective motion correction with optical markerless motion tracking is used to remove artifacts and blurring due to bulk motion whereas locally low-rank regularization is used to correct remaining artifacts due to the background phase variations from scan to scan. We present the results in healthy adult volunteers, demonstrating high-resolution diffusion-weighted images and FA images under different motion patterns with PMC.
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