Vendor-native implementations can lead to unaccounted variance in quantitative MRI (qMRI). The purpose of this study is to show that fully transparent qMRI workflows coupled with VEndor-NeUtral Sequences (VENUS) improve multicenter reproducibility of quantitative MRI maps across three scanners by two vendors, in phantoms and in-vivo. We developed and deployed a vendor-neutral 3D spoiled gradient-echo (SPGR) sequence on three commercial scanners and showed that vendor-neutral qMRI maps of T1, MTR and MTsat outperform their vendor-native counterparts in terms of reproducibility.
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