Abstract #0403

Title Fractal Analysis of the BOLD Signal in Preterm Infants Scanned Shortly After Birth and at Term-Equivalent Age

Alexander Mark Weber^1,2, Johann Drayne^1,2, Olivia Campbell^1,2, Cecil Chau^2,3, Steven Miller⁴, and Ruth Grunau^2,3

¹Brain, Behaviour & Development, BC Children's Hospital Research Institute, Vancouver, BC, Canada, ²University of British Columbia, Vancouver, BC, Canada, ³BC Children's Hospital Research Institute, Vancouver, BC, Canada, ⁴Division of Neurology and Centre for Brain & Mental Health, SickKids, Toronto, ON, Canada

Synopsis

It has been found that fractal analysis of the BOLD signal in fMRI can be used to measure brain functioning, development, and health. There has to our knowledge, however, not been any fractal analysis fMRI studies done in newborns. By computing the mean Hurst exponent in 9 resting state networks and in a grey matter mask. We found the largest increase in the Hurst exponent between pre-term and term equivalent aged subjects was in the motor and visual network. This motivates the need of further exploration of fractal analysis as a measure of brain dynamics in pre-term infants.

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