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Abstract #0403

Title Fractal Analysis of the BOLD Signal in Preterm Infants Scanned Shortly After Birth and at Term-Equivalent Age

Alexander Mark Weber1,2, Johann Drayne1,2, Olivia Campbell1,2, Cecil Chau2,3, Steven Miller4, and Ruth Grunau2,3
1Brain, Behaviour & Development, BC Children's Hospital Research Institute, Vancouver, BC, Canada, 2University of British Columbia, Vancouver, BC, Canada, 3BC Children's Hospital Research Institute, Vancouver, BC, Canada, 4Division of Neurology and Centre for Brain & Mental Health, SickKids, Toronto, ON, Canada


It has been found that fractal analysis of the BOLD signal in fMRI can be used to measure brain functioning, development, and health. There has to our knowledge, however, not been any fractal analysis fMRI studies done in newborns. By computing the mean Hurst exponent in 9 resting state networks and in a grey matter mask. We found the largest increase in the Hurst exponent between pre-term and term equivalent aged subjects was in the motor and visual network. This motivates the need of further exploration of fractal analysis as a measure of brain dynamics in pre-term infants.

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