Abstract #0412

Effects of Aging and Muscle Degeneration on Metabolic Response to High-Intensity Muscle Contraction in Mice by Phosphorus-31 MRS

Kihwan Kim¹, Yuran Zhu², Yudu Li³, Zhi-Pei Liang ^3,4, and Xin Yu^2,5

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Biomedical Engineering, Case Western Reserve University, cleveland, OH, United States, ³Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Beckman Institute for advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Case Center for Imaging Research, Case Western Reserve University, cleveland, OH, United States

Synopsis

In this study, ³¹P-MRS was employed to evaluate the effects of aging and muscle degeneration on metabolic response to stimulation-induced, high-intensity muscle contraction in two age groups of C57BL/6 and mdx mice, a mouse model of moderate muscular dystrophy. Significant, age-dependent differences in mitochondrial oxidative capacity and creatine kinase activity after muscle stimulation were observed between C57BL/6 and mdx mice, suggesting a positive metabolic response to muscle contraction that can be modulated by aging and muscle degeneration.

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