Effects of Aging and Muscle Degeneration on Metabolic Response to High-Intensity Muscle Contraction in Mice by Phosphorus-31 MRS
Kihwan Kim1, Yuran Zhu2, Yudu Li3, Zhi-Pei Liang 3,4, and Xin Yu2,5
1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Biomedical Engineering, Case Western Reserve University, cleveland, OH, United States, 3Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Beckman Institute for advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5Case Center for Imaging Research, Case Western Reserve University, cleveland, OH, United States
In this study, 31P-MRS was employed to evaluate the effects of aging and muscle degeneration on metabolic response to stimulation-induced, high-intensity muscle contraction in two age groups of C57BL/6 and mdx mice, a mouse model of moderate muscular dystrophy. Significant, age-dependent differences in mitochondrial oxidative capacity and creatine kinase activity after muscle stimulation were observed between C57BL/6 and mdx mice, suggesting a positive metabolic response to muscle contraction that can be modulated by aging and muscle degeneration.
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