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Abstract #0415

Translational exploration of dynamic functional connectivity changes in Alzheimer’s disease patients and Thy-Tau22 mice at the prodromal stage

Laetitia Degiorgis1, Elena Chabran1, Marion Sourty1, Frédéric Blanc1,2, and Laura-Adela Harsan1,3
1ICube Laboratory UMR 7357, Strasbourg University and CNRS, Strasbourg, France, 2Centre Mémoire de Ressources et de Recherche (CM2R), Strasbourg University Hospitals, Neurology and Geriatrics units, Strasbourg, France, 3Department of Biophysics and Nuclear Medicine, Strasbourg University Hospitals, Strasbourg, France


Between-species comparisons become essential to validate findings from animal models. In case of Alzheimer’s disease (AD) especially important is to evaluate their predictive potential for the sporadic form and to assess their relevance for the early stages of pathology. Therefore, we used dynamic resting-state functional connectivity to investigate and comparatively assess changes in early AD patients and prodromal Thy-Tau22 mice, a mouse model of tauopathy. We highlighted between-species similarities showing less dynamic communication of brain areas in diseased groups than in controls, and comparable modifications of memory and default mode-like networks in early AD and prodromal Thy-Tau22 mice.

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