Between-species comparisons become essential to validate findings from animal models. In case of Alzheimer’s disease (AD) especially important is to evaluate their predictive potential for the sporadic form and to assess their relevance for the early stages of pathology. Therefore, we used dynamic resting-state functional connectivity to investigate and comparatively assess changes in early AD patients and prodromal Thy-Tau22 mice, a mouse model of tauopathy. We highlighted between-species similarities showing less dynamic communication of brain areas in diseased groups than in controls, and comparable modifications of memory and default mode-like networks in early AD and prodromal Thy-Tau22 mice.
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