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Abstract #0424

Laminar Myeloarchitectonic Mapping using T1- and T2-weighted MRI in Macaque Monkeys

Joonas A. Autio1, Takayuki Ose1, Akiko Uematsu1, Takuro Ikeda1, Masahiro Ohno1, Yuki Masamoto1, Henry Kennedy2,3, David C. Van Essen4, Matthew F. Glasser4,5, and Takuya Hayashi1
1Center for Biosystems Dynamics Research, RIKEN, Kobe, Japan, 2Inserm, Stem Cell and Brain Research Institute, Lyon, France, 3State Key Laboratory of Neuroscience, Institute of Neuroscience, Shanghai, China, 4Department of Neuroscience, Washington University School of Medicine, St Louis, MO, United States, 5Department of Neuroscience, Washington University School of Medicine, St Louis, MT, United States


Classically, many cortical areas have been defined by their distinctive myeloarchitectonic laminar profiles. Here, we explore laminar transitions by adjusting the structural MRI resolution according to the average width of standard six cortical layers and by attenuating Gibbs’ ringing artefact using T1w/T2w-FLAIR ratio in anesthetized macaque monkeys. We demonstrate that laminar similarity measures, together with the ‘Human Connectome Project’-style midthickness weighted gradients, reveal sharp transitions between several cortical areas in heavily and lightly myelinated brain areas providing mutually supportive information of cortical organization.

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