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Abstract #0439

Anisotropic Mechanical Properties of White Matter Tracts in Aging via Transversely Isotropic MR Elastography

Diego A Caban-Rivera1, Daniel R Smith1, Matthew DJ McGarry2, L. Tyler Williams1, Grace McIlvain1, Elijah EW Van Houten3, Keith D Paulsen2, Phil V Bayly4, and Curtis L Johnson1
1University of Delaware, Newark, DE, United States, 2Dartmouth College, Hanover, NH, United States, 3Université de Sherbrooke, Sherbrooke, QC, Canada, 4Washington University in St. Louis, St. Louis, MO, United States


This study combined multi-excitation MR Elastography (ME-MRE) with a transversely isotropic inversion nonlinear inversion algorithm and diffusion tensor imaging (DTI) fiber directions to investigate anisotropic white matter tract integrity in aging. Participants were 5 older adults and 17 young adults. MRE outcomes include substrate shear modulus, μ, shear anisotropy, φ, tensile anisotropy, ζ, and DTI measures were also examined. Shear and tensile anisotropies were significantly different in the Corona Radiata and Superior Longitudinal Fasciculus. Diffusion measures were significantly different between groups in most tracts. These results suggest sensitivity of anisotropic properties to biological changes along white matter tracts in aging.

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