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Abstract #0477

Size Matters: Correct diagnoses of MRI based renal oxygenation assessment by monitoring kidney size

Jason Michael Millward1,2, Kathleen Cantow3, Thomas Gladytz1, Sonia Waiczies1,2, Thoralf Niendorf1,2, and Erdmann Seeliger3
1Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Institute of Physiology, Charite´ - Universitätsmedizin Berlin, Berlin, Germany


Tissue hypoxia occurs during acute kidney injury. MRI-based measurement of renal T2* and T2 could become a non-invasive surrogate marker of tissue oxygenation. However, the relationship between renal oxygenation and T2*,T2 is confounded by changes in the blood and tubular volume fractions, which are often accompanied by changes in kidney size (KS). We performed serial MRI scans along with clinically-realistic interventions acutely affecting renal oxygenation, applied directly while rats were in the scanner. We show that changes in KS correlate with changes in renal T2*,T2, underscoring that monitoring KS is necessary for correct interpretation of renal oxygenation derived from MRI.

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