Abstract #0477

Size Matters: Correct diagnoses of MRI based renal oxygenation assessment by monitoring kidney size

Jason Michael Millward^1,2, Kathleen Cantow³, Thomas Gladytz¹, Sonia Waiczies^1,2, Thoralf Niendorf^1,2, and Erdmann Seeliger³

¹Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, ²Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, ³Institute of Physiology, Charite´ - Universitätsmedizin Berlin, Berlin, Germany

Synopsis

Tissue hypoxia occurs during acute kidney injury. MRI-based measurement of renal T₂* and T₂ could become a non-invasive surrogate marker of tissue oxygenation. However, the relationship between renal oxygenation and T₂*,T₂ is confounded by changes in the blood and tubular volume fractions, which are often accompanied by changes in kidney size (KS). We performed serial MRI scans along with clinically-realistic interventions acutely affecting renal oxygenation, applied directly while rats were in the scanner. We show that changes in KS correlate with changes in renal T₂*,T₂, underscoring that monitoring KS is necessary for correct interpretation of renal oxygenation derived from MRI.

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