Diffusion-weighted imaging in renal tissue is a complex interplay of microstructural and microcirculation effects, which are often quantified with diffusion tensor imaging (DTI) or intravoxel incoherent motion (IVIM), as well as hybrid models such as Renal Flow and Microstructure AnisotroPy (REFMAP). This work measures the modulation of these effects with cardiac phase and with flow compensated (FC) diffusion gradient waveforms. Results show that both cardiac phase and FC affect diffusion metrics signficantly in cortex and medulla, and suggest that these experimental tools may in the future be leveraged to increase biophysical specificity of renal diffusion MRI metrics.
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