Abstract #0483

Noninvasive assessment of unilateral ureter obstruction using dynamic contrast-enhanced MR-CEST urography

Julia Stabinska¹, Aruna Singh^1,2, Farzad Sedaghat², Max Kates³, Yuguo Li^1,2, and Michael T. McMahon^1,2

¹F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ²The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³The James Buchanan Brady Urological Institute, Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

The extent of recovery of renal function in patients with urinary tract obstructions depends on early diagnosis and prompt intervention. In the present study, we employed dynamic contrast-enhanced MR-CEST urography to noninvasively assess kidney function in mice with unilateral ureter obstruction (UUO) at two time points (day 1 and 2) after UUO surgery. Using a dynamic CEST MRI protocol, we were able to detect a slight increase in pH values (pH 6.74 ± 0.08 and 6.62 ± 0.04 in the UUO and contralateral kidney, respectively) as well as iopamidol retention in the UUO kidney.

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