Noninvasive assessment of unilateral ureter obstruction using dynamic contrast-enhanced MR-CEST urography
Julia Stabinska1, Aruna Singh1,2, Farzad Sedaghat2, Max Kates3, Yuguo Li1,2, and Michael T. McMahon1,2
1F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 2The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3The James Buchanan Brady Urological Institute, Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States
The extent of recovery of renal function in patients with urinary tract obstructions depends on early diagnosis and prompt intervention. In the present study, we employed dynamic contrast-enhanced MR-CEST urography to noninvasively assess kidney function in mice with unilateral ureter obstruction (UUO) at two time points (day 1 and 2) after UUO surgery. Using a dynamic CEST MRI protocol, we were able to detect a slight increase in pH values (pH 6.74 ± 0.08 and 6.62 ± 0.04 in the UUO and contralateral kidney, respectively) as well as iopamidol retention in the UUO kidney.
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