Separating Tissue Components in Ex-vivo Mouse Brain with Joint Diffusion-Relaxation MRI and InSpect
Paddy J. Slator1, Noam Shemesh2, and Andrada Ianus2
1Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 2Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal
We identify and map intra-voxel tissue components in the mouse brain by applying InSpect, a data-driven approach for quantitative MRI analysis, to high resolution ex-vivo T2-diffusion MRI. Our approach reveals distinct tissue microenvironments with minimal model assumptions, revealing features that cannot be seen in diffusion kurtosis maps.
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