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Abstract #0573

Family of Novel Hyperpolarized 13C Molecular Imaging Probes Monitors Real-Time Oxidative Stress in Cancer Metabolism

Kazutoshi Yamamoto1, Yohei Kondo2, Ana Opina3, Deepak Sail3, Natarajan Raju3, Burchelle Blackman3, Ronja M. Malinowski4, Tomohiro Seki1, Shun Kishimoto1, Nobu Oshima1, Yasunori Otowa1, Kota Yamashita1, Daniel R. Crooks1, Jeffrey R. Brender1, Hiroshi Nonaka2, Yutaro Saito2, Peter L. Choyke1, Jan H. Ardenkjær-Larsen 4, James B. Mitchell1, W. Marston Linehan1, Rolf Swenson3, Shinsuke Sando2, and Murali C. Krishna1
1National Cancer Institute, National Institutes of Health, Bethesda, MD, United States, 2Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Japan, 3National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD, United States, 4Department of Health Technology, Technical University of Denmark, Lyngby, Denmark


Molecular imaging can personalize cancer therapies by monitoring treatment responses, where hyperpolarized MRI is becoming an increasingly critical methodology. However, the limited number of available probes, which can interrogate key physiology/biochemistry related to targeted diseases, remains one of the major challenges in this growing field. In this presentation, we successfully demonstrate, for the first time, the advantages of newly synthesized 13C-Glutathione and 13C-N-acetyl cysteine probe in vivo redox status in a complementary manner. This approach serves as powerful non-invasive biomarkers to assess oxidative stress, which plays a vital role in various diseases and can be translatable to the clinical diagnosis.

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