Molecular imaging can personalize cancer therapies by monitoring treatment responses, where hyperpolarized MRI is becoming an increasingly critical methodology. However, the limited number of available probes, which can interrogate key physiology/biochemistry related to targeted diseases, remains one of the major challenges in this growing field. In this presentation, we successfully demonstrate, for the first time, the advantages of newly synthesized 13C-Glutathione and 13C-N-acetyl cysteine probe in vivo redox status in a complementary manner. This approach serves as powerful non-invasive biomarkers to assess oxidative stress, which plays a vital role in various diseases and can be translatable to the clinical diagnosis.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords