Ultra-high field normative quantitative susceptibility mapping (QSM) in children and cortical pathology in drug-resistant focal epilepsy
Chiara Casella1,2, Katy Vecchiato1,2,3, Ayse Sila Dokumaci2,4, Philippa Bridgen2,4, Shaihan Malik2,4, Joseph V Hajnal2,4, Sharon Giles2,4, Jan Sedlacik1,2,4,5, Karin Shmueli2,6, Tom Wilkinson2,4, Raphael Tomi-Tricot2,4,7, David W Carmichael2,4, and Jonathan O'Muircheartaigh1,2,3,8
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2London Collaborative Ultra high field System (LoCUS), London, United Kingdom, 3Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom, 4School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 5Radiology Department, Great Ormond Street Hospital for Children, London, United Kingdom, 6Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 7MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom, 8MRC Centre for Neurodevelopmental Disorders, London, United Kingdom
We developed an analysis pipeline to explore normative QSM values in children and adolescents at 7T, and assessed the feasibility of this approach for detecting tissue-alterations in paediatric drug-resistant epilepsy. Normative values consistent with previous QSM studies were reported for deep brain regions, and normative cortical susceptibility values were described for the first time in children and adolescents at 7T. Finally, sensitivity to susceptibility changes in epileptogenic lesions was demonstrated using the analysis pipeline.
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