Abstract #0588

Ultra-high field normative quantitative susceptibility mapping (QSM) in children and cortical pathology in drug-resistant focal epilepsy

Chiara Casella^1,2, Katy Vecchiato^1,2,3, Ayse Sila Dokumaci^2,4, Philippa Bridgen^2,4, Shaihan Malik^2,4, Joseph V Hajnal^2,4, Sharon Giles^2,4, Jan Sedlacik^1,2,4,5, Karin Shmueli^2,6, Tom Wilkinson^2,4, Raphael Tomi-Tricot^2,4,7, David W Carmichael^2,4, and Jonathan O'Muircheartaigh^1,2,3,8

¹Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²London Collaborative Ultra high field System (LoCUS), London, United Kingdom, ³Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom, ⁴School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁵Radiology Department, Great Ormond Street Hospital for Children, London, United Kingdom, ⁶Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ⁷MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom, ⁸MRC Centre for Neurodevelopmental Disorders, London, United Kingdom

Synopsis

We developed an analysis pipeline to explore normative QSM values in children and adolescents at 7T, and assessed the feasibility of this approach for detecting tissue-alterations in paediatric drug-resistant epilepsy. Normative values consistent with previous QSM studies were reported for deep brain regions, and normative cortical susceptibility values were described for the first time in children and adolescents at 7T. Finally, sensitivity to susceptibility changes in epileptogenic lesions was demonstrated using the analysis pipeline.

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