Abstract #0610
Risk Factors for Perioperative Brain Lesions on MRI in Infants with Severe Congenital Heart Disease: A European Collaboration
Alexandra F Bonthrone1, Raymond Stegeman2,3,4,5,6, Maria Feldmann7, Nathalie HP Claessens2,3,4,6, Maaike Nijman2,3,4,6, Nicolaas JG Jansen3,8, Joppe Nijman3, Floris Groenendaal2,6, Linda S de Vries2, Manon JNL Benders2, Felix Haas5, Mireille N Bekker9, Thushiha Logeswaran10, Bettina Reich11, Raimund Kottke12, Cornelia Hagmann13, Bea Latal7, Hitendu Dave14, John Simpson15, Kuberan Pushparajah15,16, Conal Austin15, Christopher J Kelly1, Sophie Arulkumaran1, Mary A Rutherford1, Serena J Counsell1, Walter Knirsch17, and Johannes MPJ Breur4
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Department of Neonatology, Wilhelmina Children’s Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands, 3Department of Pediatric Intensive Care, Wilhelmina Children’s Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands, 4Department of Pediatric Cardiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands, 5Congenital Cardiothoracic Surgery, Wilhelmina Children’s Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands, 6Utrecht Brain Center, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands, 7Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland, 8Department of Pediatrics, Beatrix Children’s Hospital, University Medical Center Groningen, Groningen, Netherlands, 9Department of Obstetrics, Wilhelmina Children’s Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands, 10Pediatric Heart Center, University Hospital Giessen, Justus-Liebig-University Giessen, Giessen, Germany, 11Department of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technical University of Munich, Munich, Germany, 12Department of Diagnostic Imaging, University Children’s Hospital Zurich, Zurich, Switzerland, 13Department of Neonatology and Pediatric Intensive Care, University Children’s Hospital Zurich, Zurich, Switzerland, 14Division of Congenital Cardiovascular Surgery, Pediatric Heart Centre, University Children’s Hospital Zurich, Zurich, Switzerland, 15Paediatric Cardiology Department, Evelina London Children's Healthcare, London, United Kingdom, 16Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 17Pediatric Cardiology, Pediatric Heart Center, Department of Surgery, Children’s Research Center, University Children’s Hospital, and University of Zurich, Zurich, Switzerland
Synopsis
Infants with Congenital Heart Disease (CHD) are at risk of neurodevelopmental impairments. MRI studies have identified brain injury in infants with CHD both before and after cardiac surgery. We characterized risk factors for preoperative and new postoperative arterial ischaemic stroke (AIS), white matter injury (WMI) and cerebral sinovenous thrombosis (CSVT) in a cohort of infants with severe CHD. Balloon atrial septostomy was associated with increased risk of preoperative brain injury. Induced vaginal delivery was associated with preoperative WMI. Cardiac physiology and perioperative factors were associated with increased risk of new postoperative brain injury.
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