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Abstract #0648

Is diffusion tensor principal diffusivity aligned with axon fiber in the human brain white matter?

1Department of Radiology, University of Michigan, Ann Arbor, MI, United States


An angle offset has been identified in proton magnetic resonance transverse relaxation orientation dependencies in the human brain WM in vivo when DTI primary diffusivity direction was used as an internal reference. This angle offset has not yet been accounted for in previous studies. The present work demonstrates that the observed angle offset can be removed using an angle derived from the perpendicular and parallel diffusivities of an axially symmetric diffusion tensor regardless of axon fiber orientations. The finding from this study clearly suggests that the diffusion tensor principal diffusivity direction deviates from an axon fiber orientation in WM.

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