Longitudinal comparison of quantitative UTE lung MRI and CT biomarkers in interstitial lung disease
Ho-Fung Chan1, Timothy J Baldwin1, Harry Barker1, Neil J Stewart1, James A Eaden1,2, Paul J.C Hughes1, Nicholas D Weatherley1, Joshua Astley1,3, Bilal A Tahir1,3, Kevin M Johnson4, Ronald A Karwoski5, Brian J Bartholmai6, Marta Tibiletti7, Colm T Leonard8,9, Sarah Skeoch8,10, Nazia Chaudhuri8,9, Ian N Bruce8,9, Geoff J.M Parker7,11, Stephen M Bianchi2, and Jim M Wild1
1Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, 2Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, 3Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom, 4Radiology and Medical Physics, University of Wisconsin, Madison, WI, United States, 5Biomedical Imaging Resource, Mayo Clinic, Rochester, MN, United States, 6Radiology, Mayo Clinic, Rochester, MN, United States, 7Bioxydyn Limited, Manchester, United Kingdom, 8University of Manchester, Manchester, United Kingdom, 9Manchester University NHS Foundation Trust, Manchester, United Kingdom, 10Royal United Hospitals Bath NHS Foundation Trust, Bath, United Kingdom, 11Centre for Medical Image Computing, University College London, London, United Kingdom
UTE lung MRI approaches the diagnostic quality of CT, opening up the possibility for longitudinal follow-up of interstitial lung disease (ILD) progression. Two quantitative biomarkers of UTE lung signal were developed for monitoring longitudinal change in ILD and benchmarked against quantitative CT CALIPER measurements. Normalized UTE lung signal and UTE high percentage (based on 95% cutoff of healthy UTE lung values) was significantly different between nine healthy volunteers and sixteen ILD patients. Longitudinal change in UTE biomarkers correlated with change in CT CALIPER ILD% in the ILD patients, and most-strongly correlated to CT ground-glass changes in the lung parenchyma.
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