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Abstract #0676

Deuterium magnetic resonance spectroscopy using 2H-pyruvate allows in vivo imaging of tumor burden and response to therapy

Georgios Batsios1, Celine Taglang1, Meryssa Tran1, Anne Marie Gillespie1, Sabrina Ronen1, Joseph Costello2, and Pavithra Viswanath1
1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Neurological Surgery, UCSF, San Francisco, CA, United States


Telomerase reverse transcriptase (TERT) is essential for tumor proliferation and is an attractive therapeutic target. Non-invasive methods of imaging TERT can report on tumor proliferation and response to therapy. Here, we show that 2H-MRS following administration of [U-2H]pyruvate non-invasively monitors TERT expression in clinically relevant patient-derived glioma models. Importantly, imaging TERT using [U-2H]pyruvate provides a readout of response to targeted TERT inhibitors and standard of care chemotherapy in vivo, at early timepoints that precedes MRI-detectable anatomical alterations. Clinical translation of our results can enable non-invasive assessment of TERT expression in vivo and, thereby, aid in imaging response to anti-cancer therapies.

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