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Abstract #0689

Comparing Diffusion MRI Metrics with 3D Nissl Staining of Whole Mouse Brain at Microscopic Resolution

Nian Wang1,2 and Surendra Maharjan1
1Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, United States, 2Stark Neurosciences Research Institute, Indiana University, Indianapolis, IN, United States


Magnetic resonance imaging (MRI) offers a noninvasive method for characterizing brain neuroanatomy and provides insights into various disease processes. Diffusion MRI (dMRI) has been used for assessment of tissue microstructure due to its exquisite sensitivity to finer scales far above imaging resolution. The recently developed Allen Mouse Brain Common Coordinate Framework (CCFv3) has opened the opportunities to integrate multimodal and multiscale datasets of whole mouse brain in 3D, and thus, this approach can be used to compare quantitative MRI parameters with conventional histology features throughout the whole brain.

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