Meeting Banner
Abstract #0696

Optimization of dual flip angle T1 mapping at 7T with B1 transmit variability

Jyoti Mangal1,2, Sila Ayse Dokumaci1,2, David Leitao1,2, Raphael Tomi-Tricot1,2,3, Amer Ajanovic1,2, Stephen Ogier1,2, Tom Wilkinson1,2, Sharon Giles1,2, Pip Bridgen1,2, Claudia Prieto1, Joseph V Hajnal1,2, Shaihan Malik1,2, and David W Carmichael1,2
1Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2London Collaborative Ultra high field System (LoCUS), King’s College London, London, United Kingdom, 3MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom


Quantitative MRI at 7T has advantages of enhanced resolution and uniform tissue contrast however protocol optimisation can be challenging as B1(+) field variability is increased. We maximized the precision of T1 estimation for a dual flip angle SPGR acquisition using Cramer-Rao Lower Bound framework and validated the results using a Monte Carlo simulation and both phantom and in-vivo experiments. For a TR of 20ms, simulations suggested optimal flip angles of 4° and 26° similar to in-vivo results of 4° and 28°. By accounting for other parameters, the CRLB framework can be flexibly extended to optimize more complex mapping protocols.

This abstract and the presentation materials are available to members only; a login is required.

Join Here