Quantitative MRI at 7T has advantages of enhanced resolution and uniform tissue contrast however protocol optimisation can be challenging as B1(+) field variability is increased. We maximized the precision of T1 estimation for a dual flip angle SPGR acquisition using Cramer-Rao Lower Bound framework and validated the results using a Monte Carlo simulation and both phantom and in-vivo experiments. For a TR of 20ms, simulations suggested optimal flip angles of 4° and 26° similar to in-vivo results of 4° and 28°. By accounting for other parameters, the CRLB framework can be flexibly extended to optimize more complex mapping protocols.
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