Sensitivity of dMRI with TBSS analysis to WM pathology in SLE: influence of field strength, acquisition approach and post-processing strategy
Evgenios N. Kornaropoulos1,2, Stefan Winzeck2,3, Linda Knutsson4,5,6, Marta M. Correia7, Pia C. Sundgren1,8,9, and Markus Nilsson1
1Diagnostic Radiology, Lund University, Lund, Sweden, 2Division of Anaesthesia, University of Cambridge, Cambridge, United Kingdom, 3Computing, Imperial College London, London, United Kingdom, 4Lund University, Lund, Sweden, 5Johns Hopkins University, Baltimore, MD, United States, 6Kennedy Krieger Institute, Baltimore, MD, United States, 7MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom, 8Skane University Hospital, Lund, Sweden, 9BioImaging Center, Lund University, Lund, Sweden
We examined whether more advanced dMRI increase the sensitivity to white matter pathology in systemic lupus erythematosus. Specifically, we examined whether more advanced acquisitions (DKI versus DTI, 7T versus 3T) and more complex processing (e.g. denoising, Gibbs-ringing removal) provide increased sensitivity. Tract-based spatial statistical analysis was applied, and the fraction of significant voxels in the white matter skeleton was used as the sensitivity metric. Results showed that the choice of the acquisition protocol had a greater impact on sensitivity than the choice of the post-processing strategy. 3T-DTI was more sensitive than 3T-DKI and 7T-DTI, regardless of the applied post-processing pipeline.
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