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Abstract #0714

Increased structural connectivity in high schizotypy: a possible protective mechanism against schizophrenia.

Eirini Messaritaki1, Sonya Foley1, Kali Barawi2, and Derek K Jones1
1Psychology, Cardiff University, Cardiff, United Kingdom, 2Medicine, Cardiff University, Cardiff, United Kingdom


This work explores the link between brain structural connectivity and schizotypy in healthy participants. We found evidence of higher structural connectivity in the sensorimotor network of high-schizotypy participants compared to those with low schizotypy. Weaker evidence was also found for alterations in the auditory, default-mode and visual networks. In contrast, no significant differences were found in the structural connectivity of the whole-brain or limbic networks. The higher connectivity possibly shields these participants from schizophrenia. Our results agree with the results of works proposing that deficiencies in the sensorimotor brain network should be investigated as possible causes for schizophrenia.

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