Abstract #0717
Frontal and Temporal Cortical Myelination Associations with Cognition Revealed by a Novel T1w/T2w-based Marker in Subjective Cognitive Decline
Yu Veronica Sui1, Arjun V Masurkar2,3,4, Karyn Marsh2, Barry Reisberg5, Thomas Wisniewski2,3,5,6, Henry Rusinek1,5, and Mariana Lazar1
1Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 2Center for Cognitive Neurology, Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States, 3Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, United States, 4Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY, United States, 5Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, United States, 6Department of Pathology, New York University Grossman School of Medicine, New York, NY, United States
Synopsis
Identifying early changes associated with Alzheimer’s Disease (AD) and separating pathological from normal brain aging is a key step in AD treatment development. It has been proposed that a neuropathological retrogenesis heralded by cortical demyelination underlies the behavioral retrogenesis characterizing AD. As one of the earliest behavioral manifestations of AD, subjective cognitive decline (SCD) is a major research target, however, few studies have discovered reliable neural correlates at this stage. Here, using a novel cortical profile approach, we examined the cortical gradient of T1w/T2w, a putative myelin marker, in SCD and healthy control participants and its association with cognition.
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