Abstract #0717

Frontal and Temporal Cortical Myelination Associations with Cognition Revealed by a Novel T1w/T2w-based Marker in Subjective Cognitive Decline

Yu Veronica Sui¹, Arjun V Masurkar^2,3,4, Karyn Marsh², Barry Reisberg⁵, Thomas Wisniewski^2,3,5,6, Henry Rusinek^1,5, and Mariana Lazar¹

¹Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Center for Cognitive Neurology, Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States, ³Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, United States, ⁴Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY, United States, ⁵Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, United States, ⁶Department of Pathology, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Identifying early changes associated with Alzheimer’s Disease (AD) and separating pathological from normal brain aging is a key step in AD treatment development. It has been proposed that a neuropathological retrogenesis heralded by cortical demyelination underlies the behavioral retrogenesis characterizing AD. As one of the earliest behavioral manifestations of AD, subjective cognitive decline (SCD) is a major research target, however, few studies have discovered reliable neural correlates at this stage. Here, using a novel cortical profile approach, we examined the cortical gradient of T1w/T2w, a putative myelin marker, in SCD and healthy control participants and its association with cognition.

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