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Abstract #0722

Hippocampal Subfield Property Differences in Amnestic Mild Cognitive Impairment Measured with MR Elastography

Peyton L Delgorio1, Lucy V Hiscox2, Grace McIlvain1, Alexis A Merritt1, Alexa M Diano1, Mary K Kramer1, Kyra E Twohy1, James M Ellison3, Alyssa Lanzi1, Matthew L Cohen1, Christopher R Martens1, and Curtis L Johnson1
1University of Delaware, Newark, DE, United States, 2University of Bath, Bath, United Kingdom, 3ChristianaCare Health System, Newark, DE, United States


The aim of this study was to determine whether magnetic resonance elastography (MRE) could sensitively detect mechanical property alterations in the hippocampal subfields due to amnestic mild cognitive impairment (aMCI) - a prodromal stage of Alzheimer’s disease (AD). Results show that entorhinal cortex viscoelasticity was significantly lower in aMCI participants. Further, the entorhinal cortex did not display significant volume differences due to aMCI, which demonstrates how MRE may yield more information about the health of a region known to harbor AD pathology. These results suggest that hippocampal subfield MRE measures show potential for use as an imaging biomarker of disease.

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