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Abstract #0731

Myocardial Metabolic Changes Detected Post-COVID-19 with Hyperpolarized Pyruvate

Vlad G Zaha1, Junjie Ma1, Jae Mo Park1, Munes Fares1, Nicholas Hendren1, Spencer Carter1, Anjali Rao1, Ravi Vamsee1, Madhusudan Ganigara1, Mohamed Nagiub1, Mohammad Tarique Hussain1, Ricardo La Hoz1, James Cutrell1, Pradeep Mammen1, Mark Drazner1, James de Lemos1, Craig Malloy1, and Justin Grodin1
1University of Texas Southwestern Medical Center, Dallas, TX, United States


Noninvasive detection of myocardial inflammation can be challenging. Up to 73% of patients recovered from COVID-19 had increased native T1 on cardiac MRI1 representing inflammation or edema. Therefore, we tested whether hyperpolarized (HP) [1-13C]pyruvate detectis post-COVID-19 inflammation in the myocardium. HP [1-13C]lactate has been suggested as a surrogate imaging marker of inflammation in the heart2,3, attributed to increased glycolytic activity in infiltrating white cells plus a possible increase in activity of lactate dehydrogenase. We demonstrate the feasibility of imaging with HP [1-13C]pyruvate as noninvasive method to detect metabolic changes that may identify cardiac inflammation in the convalescent stage after COVID-19.

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