Abstract #0745
Prediction of survival in paediatric brain tumour patients using multicentre leakage-corrected perfusion MRI
Stephanie Withey1,2,3, Lesley MacPherson4, Adam Oates4, Stephen Powell3, Jan Novak2,3,5, Laurence Abernethy6, Barry Pizer7, Richard Grundy8, Paul S. Morgan8,9,10, Simon Bailey11, Dipayan Mitra12, Theodoros N. Arvanitis2,13, Dorothee P. Auer10,14,15, Shivaram Avula6, and Andrew C. Peet2,3
1RRPPS, University of Birmingham NHS Foundation Trust, Birmingham, United Kingdom, 2Oncology, Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham, United Kingdom, 3Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom, 4Radiology, Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham, United Kingdom, 5Department of Psychology, Aston University, Birmingham, United Kingdom, 6Radiology, Alder Hey Children’s NHS Foundation Trust, Liverpool, United Kingdom, 7Oncology, Alder Hey Children’s NHS Foundation Trust, Liverpool, United Kingdom, 8The Children’s Brain Tumour Research Centre, University of Nottingham, Nottingham, United Kingdom, 9Medical Physics, Nottingham University Hospitals, Nottingham, United Kingdom, 10Division of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom, 11Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom, 12Neuroradiology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom, 13Institute of Digital Healthcare, University of Warwick, Coventry, United Kingdom, 14Nottingham University Hospitals Trust, Neuroradiology, Nottingham, United Kingdom, 15NIHR Nottingham Biomedical Research Centre, Nottingham, United Kingdom
Synopsis
Dynamic susceptibility (DSC-) MRI provides measures of relative cerebral blood volume (rCBV) in paediatric brain tumours. Correction of rCBV for the effects of contrast agent leakage can be done using post-processing techniques. Eighty-five patients with a range of paediatric brain tumours underwent DSC-MRI scans at 4 centres using variable protocols. Leakage-corrected and uncorrected DSC-MRI parameters were calculated and patients were followed up. Median DSC-MRI parameters significantly predicted overall survival.
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