Mapping the myelin bilayer with short-T2 MRI: Validation studies
Emily Louise Baadsvik1, Markus Weiger1, Romain Froidevaux1, Wolfgang Faigle2, Benjamin Victor Ineichen3, and Klaas Paul Pruessmann1
1Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland, 2Neuroimmunology and MS Research Section, Neurology Clinic, University of Zurich, University Hospital Zurich, Zurich, Switzerland, 3Department of Neuroradiology, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland
Various techniques for myelin mapping based on signal from the lipid-protein bilayer have been proposed, and a common way of validating these techniques is using ex-vivo tissue samples. However, it is still unclear to what extent experimental factors such as tissue storage conditions and processing affect MR signal. In this work, we investigate how long-term deep-frozen storage impacts tissue signal, and evaluate whether signal component mapping is feasible in non-D2O-exchanged samples. We also determine whether animal tissue can act as a substitute for human tissue and investigate signal differences between white and grey matter.
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