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Abstract #0757

Variable Flip, Blip-Up and -Down Undersampling (VUDU) Enables Motion-Robust, Distortion-Free Multi-Shot EPI

Jaejin Cho1,2, Tae Hyung Kim1,2, Borjan Gagoski2,3, Zijing Zhang4, Avery Berman1,2, Congyu Liao5, and Berkin Bilgic1,2,6
1Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children’s Hospital, Boston, MA, United States, 4State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China, 5Radiological Sciences Laboratory, Stanford University, Palo Alto, CA, United States, 6Harvard/MIT Health Sciences and Technology, Cambridge, MA, United States


We demonstrate the motion-robustness of multi-shot diffusion imaging using VUDU (Variable flip, blip-Up, and -Down Undersampling) in the brain. VUDU employs FLEET-ordering to acquire all EPI shots of a given slice successively before proceeding to the next slice and maximizes the signal using variable flip angle (vfa) excitation. It also utilizes BUDA (Blip-Up and -Down Acquisition) to eliminate B0 distortion and employs the Hankel low-rank regularization to address shot-to-shot phase variations. VUDU was able to provide high-fidelity diffusion-weighted images from in vivo data acquired during intentional head motion.

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