Abstract #0769

Beyond DW-Based Analysis of Fiber Architecture: Estimating Orientation Distributions from High Angular Resolution Susceptibility Imaging

Dimitrios G. Gkotsoulias¹, Michael Paquette¹, Cornelius Eichner¹, Roland Müller ¹, Torsten Schlumm¹, Niklas Alsleben¹, Jingjia Chen², Carsten Jäger¹, Jennifer Jaffe^3,4, André Pampel¹, Catherine Crockford^3,4, Roman Wittig^3,4, Alfred Anwander¹, Chunlei Liu², and Harald Möller¹

¹Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ²Department of Electrical Engineering and Computer Sciences, UC Berkeley, Berkeley, CA, United States, ³Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, ⁴Tai Chimpanzee Project, Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote D'ivoire

Synopsis

We present a novel approach to estimate fiber Orientation Distribution Functions (ODFs) by applying the generalized Constant Solid Angle (CSA) method to High Angular Resolution Susceptibility Imaging (HARSI) data from post-mortem chimpanzee brain. The acquisition details and analytical pipelines are presented and derived susceptibility tensor metrics and ODFs are compared to metrics derived from traditional High Angular Resolution Diffusion Imaging (HARDI). The ODFs estimated from susceptibility data indicate comparable efficiency in resolving intersecting fiber orientations compared to HARDI-ODFs and increased sensitivity to secondary direction. This suggests a potential to obtain complementary information on brain white matter microstructural properties.

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