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Abstract #0769

Beyond DW-Based Analysis of Fiber Architecture: Estimating Orientation Distributions from High Angular Resolution Susceptibility Imaging

Dimitrios G. Gkotsoulias1, Michael Paquette1, Cornelius Eichner1, Roland Müller 1, Torsten Schlumm1, Niklas Alsleben1, Jingjia Chen2, Carsten Jäger1, Jennifer Jaffe3,4, André Pampel1, Catherine Crockford3,4, Roman Wittig3,4, Alfred Anwander1, Chunlei Liu2, and Harald Möller1
1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Department of Electrical Engineering and Computer Sciences, UC Berkeley, Berkeley, CA, United States, 3Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, 4Tai Chimpanzee Project, Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote D'ivoire


We present a novel approach to estimate fiber Orientation Distribution Functions (ODFs) by applying the generalized Constant Solid Angle (CSA) method to High Angular Resolution Susceptibility Imaging (HARSI) data from post-mortem chimpanzee brain. The acquisition details and analytical pipelines are presented and derived susceptibility tensor metrics and ODFs are compared to metrics derived from traditional High Angular Resolution Diffusion Imaging (HARDI). The ODFs estimated from susceptibility data indicate comparable efficiency in resolving intersecting fiber orientations compared to HARDI-ODFs and increased sensitivity to secondary direction. This suggests a potential to obtain complementary information on brain white matter microstructural properties.

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