Microvascular Morphology Alteration Using Relaxation Rate Change with Gd-based MRI Contrast Agent in the Patient with Alzheimer’s Disease
Chang-Woo Ryu1, Xiao-Yi Guo2, HyeokJung Kwon2, Soonchan Park1, Hak Young Rhee3, A-Rang Cho4, and Geon-Ho Jahng1
1Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, 2Medicine, Kyung Hee University, Seoul, Korea, Republic of, 3Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, 4Psychiatry, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of
To assess the cerebral microvascular alteration in the demented patients relative to a non-demented population using in vivo microvascular index maps by using Gd-based contrast agent at a 3T MRI system, we included 11 non-demented participants and 11 AD patients. Compared with the non-demented group, BVf and MvWI were significantly increased in the demented group. Both mVD and VSI were only significantly decreased in the demented group at the white matter hyperintensity (WMHI) area. BVf and MvWI were significantly positively correlated with age and VSI was significantly positively correlated with MMSE.
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