Abstract #0781

Microvascular Morphology Alteration Using Relaxation Rate Change with Gd-based MRI Contrast Agent in the Patient with Alzheimer’s Disease

Chang-Woo Ryu¹, Xiao-Yi Guo², HyeokJung Kwon², Soonchan Park¹, Hak Young Rhee³, A-Rang Cho⁴, and Geon-Ho Jahng¹

¹Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ²Medicine, Kyung Hee University, Seoul, Korea, Republic of, ³Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ⁴Psychiatry, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of

Synopsis

To assess the cerebral microvascular alteration in the demented patients relative to a non-demented population using in vivo microvascular index maps by using Gd-based contrast agent at a 3T MRI system, we included 11 non-demented participants and 11 AD patients. Compared with the non-demented group, BVf and MvWI were significantly increased in the demented group. Both mVD and VSI were only significantly decreased in the demented group at the white matter hyperintensity (WMHI) area. BVf and MvWI were significantly positively correlated with age and VSI was significantly positively correlated with MMSE.

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