MTsat is more sensitive to cerebellar myelin abnormality in multiple sclerosis compared to MTR
Lisa Eunyoung Lee1,2, Irene Vavasour3, Enedino Hernandez-Torres4, Anthony Traboulsee5, Roger Tam3,5,6, Shannon Kolind3,5,7, Tom Schweizer2,8, and Jiwon Oh1,2
1Medicine (Neurology), University of Toronto, Toronto, ON, Canada, 2Medicine, Keenan Research Centre for Biomedical Research, Toronto, ON, Canada, 3Radiology, University of British Columbia, Vancouver, BC, Canada, 4Copenhagen University Hospital, Copenhagen, Denmark, 5Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada, 6Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, 7Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 8Medicine (Neurosurgery), University of Toronto, Toronto, ON, Canada
Magnetization transfer saturation (MTsat) is suggested to be superior to conventional MT ratio (MTR) in quantifying myelin as it reduces bias from T1 effect and B1 inhomogeneity and is more sensitive to tissue damage. This study aimed to compare the ability of MTsat and MTR to detect cerebellar myelin differences across multiple sclerosis (MS) subtypes and to evaluate whether MTsat or MTR demonstrates stronger correlations with clinical disability. We found that MTsat demonstrated greater group differences and more strongly correlated with clinical disability in cerebellum than MTR suggesting that MTsat may be more sensitive to cerebellar myelin abnormalities than MTR.
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