Abstract #0788

MTsat is more sensitive to cerebellar myelin abnormality in multiple sclerosis compared to MTR

Lisa Eunyoung Lee^1,2, Irene Vavasour³, Enedino Hernandez-Torres⁴, Anthony Traboulsee⁵, Roger Tam^3,5,6, Shannon Kolind^3,5,7, Tom Schweizer^2,8, and Jiwon Oh^1,2

¹Medicine (Neurology), University of Toronto, Toronto, ON, Canada, ²Medicine, Keenan Research Centre for Biomedical Research, Toronto, ON, Canada, ³Radiology, University of British Columbia, Vancouver, BC, Canada, ⁴Copenhagen University Hospital, Copenhagen, Denmark, ⁵Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada, ⁶Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, ⁷Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁸Medicine (Neurosurgery), University of Toronto, Toronto, ON, Canada

Synopsis

Magnetization transfer saturation (MTsat) is suggested to be superior to conventional MT ratio (MTR) in quantifying myelin as it reduces bias from T1 effect and B1 inhomogeneity and is more sensitive to tissue damage. This study aimed to compare the ability of MTsat and MTR to detect cerebellar myelin differences across multiple sclerosis (MS) subtypes and to evaluate whether MTsat or MTR demonstrates stronger correlations with clinical disability. We found that MTsat demonstrated greater group differences and more strongly correlated with clinical disability in cerebellum than MTR suggesting that MTsat may be more sensitive to cerebellar myelin abnormalities than MTR.

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