Local and Global aortic pulse wave velocity in the murine aortic arch assessed by 4D flow magnetic resonance imaging
Patrick Winter1,2, Kristina Andelovic2,3, Thomas Kampf2,4, Susanne Schnell1, Alma Zernecke3, Wolfgang Rudolf Bauer5, Peter Michael Jakob2, and Volker Herold2
1Department of MR Physics, University of Greifswald, Greifswald, Germany, 2Department of Experimental Physics V, University of Wuerzburg, Wuerzburg, Germany, 3Institute of Experimental Biomedicine, University Clinics Wuerzburg, Wuerzburg, Germany, 4Department of Diagnostic and Interventional Neuroradiology, University Clinics Wuerzburg, Wuerzburg, Germany, 5Department of Medical Clinic and Policlinic I, University Clinics Wuerzburg, Wuerzburg, Germany
As atherosclerosis is one of the main causes of death in industrial nations, noninvasive imaging modalities for studying its underlying mechanisms are in great demand. The quantification of hemodynamic parameters such as pulse wave velocity (PWV) assessed by flow sensitive magnetic resonance imaging (MRI) is a promising tool to observe plaque progression in preclinical models. Mostly, a global PWV value is assessed, however, previous studies already pointed to heterogeneous elasticity profiles in the presence of atherosclerotic plaques. Here, we present the measurement of local PWV values in the murine aortic arch assessed by 4D-flow MRI for spatially resolved elasticity measurements.
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