Abstract #0794

Local and Global aortic pulse wave velocity in the murine aortic arch assessed by 4D flow magnetic resonance imaging

Patrick Winter^1,2, Kristina Andelovic^2,3, Thomas Kampf^2,4, Susanne Schnell¹, Alma Zernecke³, Wolfgang Rudolf Bauer⁵, Peter Michael Jakob², and Volker Herold²

¹Department of MR Physics, University of Greifswald, Greifswald, Germany, ²Department of Experimental Physics V, University of Wuerzburg, Wuerzburg, Germany, ³Institute of Experimental Biomedicine, University Clinics Wuerzburg, Wuerzburg, Germany, ⁴Department of Diagnostic and Interventional Neuroradiology, University Clinics Wuerzburg, Wuerzburg, Germany, ⁵Department of Medical Clinic and Policlinic I, University Clinics Wuerzburg, Wuerzburg, Germany

Synopsis

As atherosclerosis is one of the main causes of death in industrial nations, noninvasive imaging modalities for studying its underlying mechanisms are in great demand. The quantification of hemodynamic parameters such as pulse wave velocity (PWV) assessed by flow sensitive magnetic resonance imaging (MRI) is a promising tool to observe plaque progression in preclinical models. Mostly, a global PWV value is assessed, however, previous studies already pointed to heterogeneous elasticity profiles in the presence of atherosclerotic plaques. Here, we present the measurement of local PWV values in the murine aortic arch assessed by 4D-flow MRI for spatially resolved elasticity measurements.

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