Abstract #0797

4D Flow MRI Analysis of Flow, Velocity, and Cardiac Flow Compartments in a Swine Model of Pulmonary Hypertension

Daniel P Seiter¹, Betty Allen^2,3, Diana M Tabima³, Timothy A Hacker⁴, Phil Corrado¹, Thekla H Oechtering⁵, Scott B Reeder^1,5, Naomi C Chesler^6,7, and Oliver Wieben^1,5

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Surgery, University of Wisconsin-Madison, Madison, WI, United States, ³Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁴Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁵Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁶Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center, University of California, Irvine, Irvine, CA, United States, ⁷Biomedical Engineering, University of California, Irvine, Irvine, CA, United States

Synopsis

Pulmonary hypertension is a known consequence of left heart failure. However, little is known about the pulmonary vascular and right ventricular changes caused by increased pulmonary venous pressure independent of left heart failure. By surgically banding the inferior pulmonary vein confluence in swine, we created pulmonary venous hypertension without damage to the left heart. Here, we report results from 4D flow MRI analysis of vessel flow, vessel velocity, cardiac flow compartments, and pressures measured via right heart catheterization in this novel model.

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