Aortic valve stenosis (AS) is one of the most frequent valve diseases in the elderly with relevant prognostic impact. Becausesufficient experimental models were lacking, we recently refined a murine model of gradable experimental AS closely mimicking disease progression in humans. Here, we aimed at developing a comprehensive MRI approach for simultaneous assessment of changes in valvular, myocardial as well as aortic function in mice. We demonstrate that in this murine model high resolution MRI is capable to reliably display transvalvular aortic flow profiles with concomitant quantification of structural and functional changes inaortic valve, left ventricle, and ascending aorta.
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