Placental MRI: The effect of maternal breath hold on T2* quantified by multi-echo gradient echo EPI
Jeffrey N Stout1, Esra Abaci Turk1, Borjan Gagoski1, Mary Katherine Manhard2,3, William H Barth, Jr.4, Elfar Adalsteinsson5,6, and P. Ellen Grant1
1Fetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, 2Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 3Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States, 4Maternal-Fetal Medicine, Massachusetts General Hospital, Boston, MA, United States, 5Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 6Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States
T2* imaging has been the focus of research into the non-invasive MRI assessment of placental function, yet the fundamental physiology that determines placental T2* is under active investigation. We explored the effect of maternal breath holding on placental T2* quantified with multi-echo GRE EPI. We quantified T2* in free-breathing and breath hold periods by identifying voxels that responded to the breath hold stimulus through fitting with a GLM, and found a consistent positive increase in T2* during breath hold. This increase may be evidence that fetal SO2 rises during mild maternal hypercapnia, as has been observed previously in instrumented animals.
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