Abstract #0812

Placental MRI: The effect of maternal breath hold on T2* quantified by multi-echo gradient echo EPI

Jeffrey N Stout¹, Esra Abaci Turk¹, Borjan Gagoski¹, Mary Katherine Manhard^2,3, William H Barth, Jr.⁴, Elfar Adalsteinsson^5,6, and P. Ellen Grant¹

¹Fetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, ²Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ³Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States, ⁴Maternal-Fetal Medicine, Massachusetts General Hospital, Boston, MA, United States, ⁵Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁶Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

T2* imaging has been the focus of research into the non-invasive MRI assessment of placental function, yet the fundamental physiology that determines placental T2* is under active investigation. We explored the effect of maternal breath holding on placental T2* quantified with multi-echo GRE EPI. We quantified T2* in free-breathing and breath hold periods by identifying voxels that responded to the breath hold stimulus through fitting with a GLM, and found a consistent positive increase in T2* during breath hold. This increase may be evidence that fetal SO2 rises during mild maternal hypercapnia, as has been observed previously in instrumented animals.

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