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Abstract #0820

Feasibility of Quantifying Myelin Water Fraction in the Fetal Guinea Pig Brain

Simran Sethi1, Lanette J. Friesen-Waldner1, Trevor P. Wade1,2, Ousseynou Sarr3, Brian Sutherland3, Timothy R.H. Regnault3,4,5, and Charles A. McKenzie1,2,5
1Medical Biophysics, Western University, London, ON, Canada, 2Robarts Research Institute, Western University, London, ON, Canada, 3Physiology and Pharmacology, Western University, London, ON, Canada, 4Obstetrics and Gynaecology, Western University, London, ON, Canada, 5Maternal, Fetal & Newborn Health, Children's Health Research Institute, Lawson Research Institution, London, ON, Canada


Myelin water fraction (MWF), a validated marker for myelin lipid, can be used to assess fetal myelination in vivo. Thus, this study aims to demonstrate the feasibility of quantifying fetal MWF. 11 pregnant guinea pigs with 38 fetuses were imaged in a 3T MRI. mcDESPOT was used to quantify MWF in the corpus callosum (CC) of the maternal brain and the CC and fornix (FOR) of the fetal brain. MWF maps were successfully generated in all fetal brains, confirming its feasibility. Maternal MWF results and comparison of fetal CC and FOR MWF results are consistent with published results.

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