Abstract #0820

Feasibility of Quantifying Myelin Water Fraction in the Fetal Guinea Pig Brain

Simran Sethi¹, Lanette J. Friesen-Waldner¹, Trevor P. Wade^1,2, Ousseynou Sarr³, Brian Sutherland³, Timothy R.H. Regnault^3,4,5, and Charles A. McKenzie^1,2,5

¹Medical Biophysics, Western University, London, ON, Canada, ²Robarts Research Institute, Western University, London, ON, Canada, ³Physiology and Pharmacology, Western University, London, ON, Canada, ⁴Obstetrics and Gynaecology, Western University, London, ON, Canada, ⁵Maternal, Fetal & Newborn Health, Children's Health Research Institute, Lawson Research Institution, London, ON, Canada

Synopsis

Myelin water fraction (MWF), a validated marker for myelin lipid, can be used to assess fetal myelination in vivo. Thus, this study aims to demonstrate the feasibility of quantifying fetal MWF. 11 pregnant guinea pigs with 38 fetuses were imaged in a 3T MRI. mcDESPOT was used to quantify MWF in the corpus callosum (CC) of the maternal brain and the CC and fornix (FOR) of the fetal brain. MWF maps were successfully generated in all fetal brains, confirming its feasibility. Maternal MWF results and comparison of fetal CC and FOR MWF results are consistent with published results.

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