Diffusion MRI reflects tissue microstructure and mean diffusivity (MD) and fractional anisotropy (FA) are often readily interpreted in terms of cellularity and cell anisotropy, respectively. Here, we investigated to which degree histological features accounts for their variations in fixed sections of meningioma tumors. Histological slices were quantified in terms of cellularity and cell anisotropy, or by a neural network. Results show that in some cases the majority of the variation can be attributed to cellularity whereas in others none. Similarly, in some samples only a minority of the variability is attributable to the variability in FA explained by neural network.
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