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Abstract #0870

Efficient Mapping of Diffusion Tensor Distribution in a Live Human Brain

Kulam Najmudeen Magdoom1,2,3, Alexandru V. Avram1,2,3, Dario Gasbarra4, Thomas Witzel5, Susie Y Huang5, and Peter J. Basser1,3
1Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Healt, Bethesda, MD, United States, 2The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States, 3Center for Neuroscience and Regenerative Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, United States, 4University of Helsinki, Helsinki, Finland, 5Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States


Electron microscopy of nervous tissue reveals a multitude of compartments separated by plasma membranes where the diffusion of water may be hindered. Diffusion tensor distribution (DTD) MRI assumes each voxel consists of an ensemble of diffusion tensors described by a tensor variate probability distribution function in line with the EM observed microstructure. In this study, we show in vivo results obtained in the living human brain using a new DTD framework on the Connectome scanner using 300 mT/m gradients and a novel time efficient and concomitant field free pulse sequence which allowed shorter echo time for a given b-value.

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