Electron microscopy of nervous tissue reveals a multitude of compartments separated by plasma membranes where the diffusion of water may be hindered. Diffusion tensor distribution (DTD) MRI assumes each voxel consists of an ensemble of diffusion tensors described by a tensor variate probability distribution function in line with the EM observed microstructure. In this study, we show in vivo results obtained in the living human brain using a new DTD framework on the Connectome scanner using 300 mT/m gradients and a novel time efficient and concomitant field free pulse sequence which allowed shorter echo time for a given b-value.
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