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Abstract #0881

MR-derived g-ratio is sensitive to longitudinal change and associated with disability progression in early multiple sclerosis

Elizabeth York1, Rozanna Meijboom1, Mark Bastin1, Agniete Kampaite1, Maria Valdes Hernandez1, Michael J. Thrippleton1, Peter Connick2, Siddharthan Chandran1,2, David P.J. Hunt1, and Adam D. Waldman1
1Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 2Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, United Kingdom


There is a pressing need for longitudinal in vivo biomarkers sensitive to heterogeneous pathology in relapsing-remitting multiple sclerosis (RRMS). The MR-g-ratio may be derived from myelin-sensitive magnetisation transfer saturation (MTsat) and multishell diffusion-weighted MRI but its relevance as a longitudinal biomarker and correlate of disability progression in RRMS is previously unexplored. Fifty-nine patients with recently diagnosed RRMS contributed g-ratio data at baseline and one year. G-ratio showed a significant decrease in normal-appearing white matter (NAWM) but not T2 FLAIR white matter lesions over one year. Both g-ratio in NAWM and lesions were, however, associated with clinical disability progression.

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