Abstract #0887
Quantitative MRI measures of thalamic microstructural integrity in patients with multiple sclerosis
Alessandro Cagol1, Reza Rahmanzadeh1, Muhamed Barakovic1, Po-Jui Lu1, Matthias Weigel2, Lester Melie-Garcia1, Antoine Lutti3, Than D. Nguyen4, Yi Wang4, Jens Kuhle5, Ludwig Kappos1, and Cristina Granziera1
1Translational Imaging in Neurology (ThINK) Basel, Department of Biomedical Engineering, Translational Imaging in Neurology (ThINK) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland. Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland, Basel, Switzerland, 2Translational Imaging in Neurology (ThINK) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland. Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland. Division of Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland, Basel, Switzerland, 3Laboratory for Research in Neuroimaging, Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Switzerland, Lausanne, Switzerland, 4Department of Radiology, Weill Cornell Medical College, New York, NY, USA, New York, NY, United States, 5Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland, Basel, Switzerland
Synopsis
Thalamus represents a pivotal structure to study MS-associated neurodegeneration. In this study we investigated the alterations in thalamic microstructure of MS patients by using magnetization transfer saturation (MTsat), T1-relaxometry, and myelin water fraction (MWF). Compared to healthy controls (HCs), MS patients presented significant modifications in the thalamic quantitative MRI metrics, suggesting ongoing microstructural and myelin loss. The thalamic quantitative MRI metrics explored showed variable degrees of association with MS lesion burden, brain atrophic changes, as well as with clinical and cognitive disability.
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