Abstract #0903

Optimization and evaluation of inversion pulses for background suppressed pseudo-Continuous Arterial Spin Labeling at 7T

Chenyang Zhao¹, Kai Wang¹, Christina Graf², Rudolf Stollberger², and Danny JJ Wang^1,3

¹Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Institute of Medical Engineering, Graz University of Technology, Graz, Austria, ³Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States

Synopsis

Background suppression (BS) of pseudo-Continuous Arterial Spin Labeling (pCASL) needs to be optimized at 7T to ameliorate the ASL signal loss caused by the low inversion efficiency (IE) of BS due to B1 inhomogeneity. In this study, the original HS pulse used as BS at 3T was assessed at 7T, and four non-selective inversion pulses, including HS, WURST, OPTIM, and pTx adiabatic, were optimized and evaluated in phantom and in-vivo studies. Less than 80% IE achieved by the original HS pulse was improved to 85% by optimized pulses. Markedly higher tSNR was reported in pCASL with the optimized pulses.

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