Background suppression (BS) of pseudo-Continuous Arterial Spin Labeling (pCASL) needs to be optimized at 7T to ameliorate the ASL signal loss caused by the low inversion efficiency (IE) of BS due to B1 inhomogeneity. In this study, the original HS pulse used as BS at 3T was assessed at 7T, and four non-selective inversion pulses, including HS, WURST, OPTIM, and pTx adiabatic, were optimized and evaluated in phantom and in-vivo studies. Less than 80% IE achieved by the original HS pulse was improved to 85% by optimized pulses. Markedly higher tSNR was reported in pCASL with the optimized pulses.
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