Establishing ADC repeatability is important for clinical translation of quantitative DWI. Pelvic ADC repeatability in healthy men and premenopausal women are not well-defined. Four men were scanned twice and six women were scanned each week of their normal 28-day menstrual cycle using a 3.0T scanner. Prostate, cervix, and uterine tissue ROIs were drawn to calculate median ADC values. Minimum reliably detectable ADC change (RC) was estimated at 16% and 11% within the prostatic peripheral and transition zones, respectively. Female reproductive tissue ADCs and repeatability varied across the menstrual cycle, with the greatest RCs displayed by endometrium (40%) and cervix (36%).
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