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Abstract #0968

Female patients with atopic dermatitis have reduced functional connectivity in the precuneus and inferior parietal lobe

Tie-Qiang Li1, Klas Nordlind2, Elvar Theodorsson3, and Tomas Jonsson4
1Karolinska Institutet, Stockholm, Sweden, 2Division of Dermatology and Venereology, Karolinska Institutet, Stockholm, Sweden, 3Department of Biomedical and Clinical Science, Linköping University, Linköping, Sweden, 4CLINTEC, Karolinska Institutet, Stockholm, Sweden


A cohort of 32 atopic dermatitis (AD) patients and 32 matched healthy controls (HC) were recruited to study the neurological abnormalities which might be associated with this pruritic skin condition. The main findings are 1) reduced general functional connectivity in the precuneus, inferior parietal lobe and visual cortex was detected in females AD patients; 2) Severity of the symptoms was negatively correlated with functional connectivity in inferior parietal lobe, while salivary cortisol was positively associated. Resting-state fMRI can provide useful insight into the altered neurophysiology and clinically relevant assessment for the AD disorder.

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