Nuclear overhauser enhancement (NOE) mediated chemical exchange saturation transfer (CEST) effect at -3.5 ppm has shown clinical interests in diagnosing tumors. Asymmetric analysis is a fast and simple method to measure and quantify the NOE effect, but has contamination from the downfield amide proton transfer (APT) effect at 3.5 ppm. In this abstract, we provide a new NOE quantification method using asymmetric analysis of CEST signals acquired with 2pi saturation pulses (2pi-CEST) which is also fast but has reduced contamination from the APT effect.
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