Abstract #0991

Amide proton transfer-weighted MRI with multiple models DWI facilitates preoperative risk stratification of early stage endometrial carcinoma

Nan Meng^1,2, Ting Fang^1,2, Pengyang Feng³, Zhun Huang³, Jing Sun⁴, Xuejia Wang⁵, Jie Shang⁶, Kaiyu Wang⁷, Dongming Han⁵, and Meiyun Wang^1,2

¹Department of Medical Imaging, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou, China, ²Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China, ³Department of Medical Imaging, Henan University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou, China, ⁴Department of Pediatrics, Zhengzhou Central Hospital, Zhengzhou University, Zhengzhou, China, ⁵Department of MR, the First Affiliated Hospital, Xinxiang Medical University, Weihui, China, ⁶Department of Pathology, the First Affiliated Hospital, Xinxiang Medical University, Weihui, China, ⁷MR Research China, GE Healthcare, Beijing, China

Synopsis

Intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI) can fully reflect the information of water molecular diffusion, microcirculation perfusion, and tissue heterogeneity. Amide proton transfer-weighted imaging (APTWI) has unique advantages in displaying mobile proteins and polypeptides. Our results showed that IVIM, DKI, and APTWI can estimate the risk stratification of early-stage (FIGO ≤ I) endometrial carcinoma (EC), and the combination of D, MK, and MTRasym (3.5 ppm) may be an effective imaging marker for identifying low-risk and non-low-risk early-stage EC.

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