Amide proton transfer-weighted MRI with multiple models DWI facilitates preoperative risk stratification of early stage endometrial carcinoma
Nan Meng1,2, Ting Fang1,2, Pengyang Feng3, Zhun Huang3, Jing Sun4, Xuejia Wang5, Jie Shang6, Kaiyu Wang7, Dongming Han5, and Meiyun Wang1,2
1Department of Medical Imaging, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou, China, 2Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China, 3Department of Medical Imaging, Henan University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou, China, 4Department of Pediatrics, Zhengzhou Central Hospital, Zhengzhou University, Zhengzhou, China, 5Department of MR, the First Affiliated Hospital, Xinxiang Medical University, Weihui, China, 6Department of Pathology, the First Affiliated Hospital, Xinxiang Medical University, Weihui, China, 7MR Research China, GE Healthcare, Beijing, China
Intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI) can fully reflect the information of water molecular diffusion, microcirculation perfusion, and tissue heterogeneity. Amide proton transfer-weighted imaging (APTWI) has unique advantages in displaying mobile proteins and polypeptides. Our results showed that IVIM, DKI, and APTWI can estimate the risk stratification of early-stage (FIGO ≤ I) endometrial carcinoma (EC), and the combination of D, MK, and MTRasym (3.5 ppm) may be an effective imaging marker for identifying low-risk and non-low-risk early-stage EC.
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