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Abstract #0995

Comparing sliding window correlation and instantaneous phase coherence in fMRI dynamic functional connectivity analysis

Cláudia Fonseca1, Inês Esteves1, Marta Xavier1, Ana Fouto1, Amparo Ruiz-Tagle1, Nuno A. Silva2, Rita G. Nunes1, Raquel Gil-Gouveia3, Joana Cabral4, and Patrícia Figueiredo1
1Institute for Systems and Robotics, Instituto Superior T├ęcnico, University of Lisbon, Lisbon, Portugal, 2Learning Health, Hospital da Luz, Lisbon, Portugal, 3Neurology Department, Hospital da Luz, Lisbon, Portugal, 4Life and Health Sciences Research Institute, University of Minho, Braga, Portugal

Synopsis

Sliding window Pearson correlation (SW) is the most commonly used approach for estimating dynamic functional connectivity (dFC). However, instantaneous phase coherence (PC) has gained popularity as it yields frame-by-frame dFC estimates. This work aimed to compare both metrics by analysing the mean lifetime, probability of occurrence and spatial similarity of dFC states with the canonical resting-state networks (RSNs). We found that the state lifetimes increase in SW compared to PC and with window length, worsening the detection of RSNs for smaller datasets. These findings indicate that the temporal blurring induced by SW compromises the ability to detect faster network dynamics.

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